Fig. 1

The workflow of three-stage to predict metastasis risk by using DL model: (A) Demarcation of each area reported on whole slide images (WSI). Ct : central of tumor, P: periphery of tumor, R: adjacent non tumoral tissue. The pre-processing WSIs to extract the tiles and these features; (B) Features extraction by using a pre-trained DL extractor (e.g. ResNet50), (C) Deep Attention-MIL model to predict the risk of metastasis for each patient.