Table 4 Sensitivity, specificity, AUC, cut-off and asymptotic significance of parameters in study groups.

From: Serum adropin and miR-21 expression as predictors of endothelial dysfunction in type 2 diabetes mellitus and vascular complications

Healthy control vs. diabetic group without complications group

 

Sensitivity (%)

Specifity (%)

AUC

Cut-off

p

Adropin (ng/L)

90

88.9

0.971

133

< 0.001

miR-21

95.6

95

0.990

32.7

< 0.001

HbA1c (%)

71.1

95

0.921

6.1

< 0.001

CIMT (mm)

95.6

90

0.956

0.75

< 0.001

Healthy control vs. diabetic group with microvascular complications group

 

Sensitivity (%)

Specifity (%)

AUC

Cut-off

p

Adropin (ng/L)

95

95.8

0.990

116

< 0.001

miR-21

100

100

1.000

38.9

< 0.001

HbA1c (%)

87.5

95

1.000

6.1

< 0.001

CIMT (mm)

100

100

0.966

0.9

< 0.001

Healthy control vs. diabetic group with macrovascular complications group

 

Sensitivity (%)

Specifity (%)

AUC

Cut-off

p

Adropin (ng/L)

100

100

1.00

92.8

< 0.001

miR-21

100

100

1.00

50.3

< 0.001

HbA1c (%)

70

100

1.00

6.6

< 0.001

CIMT (mm)

100

100

0.918

0.9

< 0.001

Healthy control vs. coronary artery disease without diabetes mellitus group

 

Sensitivity (%)

Specifity (%)

AUC

Cut-off

p

Adropin (ng/L)

100

100

1.00

84.8

< 0.001

miR-21

100

100

1.00

78.8

< 0.001

CIMT (mm)

94.7

100

0.997

0.9

< 0.001

  1. Abbreviations: CIMT = Carotid Intima-Media Thickness; AUC = Area Under the Curve.
  2. Statistical tests: Receiver operating characteristic (ROC) curve analyses were performed to determine sensitivity, specificity, AUC, and optimal cut-off values. Asymptotic significance (p-value) was calculated for each ROC; p < 0.05 was considered significant.
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