Table 1 The effect of different inoculum concentrations on MIC (µg/mL) values.
From: Pharmacokinetics and in vivo efficacy of epetraborole against Burkholderia pseudomallei
Bacteria | Inoculum (CFU/mL) | EBO | Ceftazidime | Meropenem | Doxycycline | Chloramphenicol |
|---|---|---|---|---|---|---|
B. pseudomallei 1026b | 5 × 107 | > 32 | > 32 | > 32 | > 32 | > 32 |
B. pseudomallei 1026b | 5 × 106 | 1 | 4 | 2 | 0.5 | 8 |
B. pseudomallei 1026b | 5 × 105 | 1 | 2 | 2 | 0.25 | 4 |
B. pseudomallei 1026b | 5 × 104 | 0.5 | 2 | 1 | 0.25 | 4 |
B. pseudomallei 1026b | 5 × 103 | 0.5 | 1 | 1 | 0.13 | 2 |
B. pseudomallei MSHR 435 | 5 × 107 | > 32 | > 32 | > 32 | > 32 | > 32 |
B. pseudomallei MSHR 435 | 5 × 106 | 2 | 4 | 2 | 16 | 32 |
B. pseudomallei MSHR 435 | 5 × 105 | 1 | 4 | 2 | 4 | 16 |
B. pseudomallei MSHR 435 | 5 × 104 | 1 | 4 | 2 | 2 | 8 |
B. pseudomallei MSHR435 | 5 × 103 | 1 | 2 | 2 | 1 | 8 |
B. pseudomallei NCTC 7383 | 5 × 107 | > 32 | > 32 | > 32 | > 32 | > 32 |
B. pseudomallei NCTC 7383 | 5 × 106 | 4 | 2 | 1 | 4 | > 32 |
B. pseudomallei NCTC 7383 | 5 × 105 | 4 | 2 | 1 | 2 | > 32 |
B. pseudomallei NCTC 7383 | 5 × 104 | 4 | 2 | 1 | 2 | > 32 |
B. pseudomallei NCTC 7383 | 5 × 103 | 4 | 2 | 1 | 2 | > 32 |
E. coli ATCC 25,922 | 5 × 107 | 2 | 8 | 8 | 1 | 8 |
E. coli ATCC 25,922 | 5 × 106 | 0.5 | 0.5 | 0.063 | 0.5 | 4 |
E. coli ATCC 25,922 | 5 × 105 | 0.5 | 0.13 | 0.031 | 0.5 | 4 |
E. coli ATCC 25,922 | 5 × 104 | 0.5 | 0.13 | 0.031 | 0.5 | 4 |
E. coli ATCC 25,922 | 5 × 103 | 0.25 | 0.13 | 0.031 | 0.5 | 4 |
P. aeruginosa ATCC 27,853 | 5 × 107 | > 32 | > 32 | > 32 | > 32 | > 32 |
P. aeruginosa ATCC 27,853 | 5 × 106 | 2 | 2 | 0.5 | 16 | > 32 |
P. aeruginosa ATCC 27,853 | 5 × 105 | 0.5 | 1 | 0.25 | 8 | > 32 |
P. aeruginosa ATCC 27,853 | 5 × 104 | 0.5 | 1 | 0.25 | 8 | > 32 |
P. aeruginosa ATCC 27,853 | 5 × 103 | 0.5 | 1 | 0.25 | 4 | > 32 |
