Table 2 Plasma concentrations and area under the curve (AUC).
From: Pharmacokinetics and in vivo efficacy of epetraborole against Burkholderia pseudomallei
Plasma | 30 mg/kg EBO SC | 100 mg/kg EBO SC | 200 mg/kg EBO SC | 300 mg/kg EBO SC | 400 mg/kg EBO SC | 600 mg/kg EBO SC | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Time (h) | Mean conc. (µg/mL) | SD | Mean conc. (µg/mL) | SD | Mean conc. (µg/mL) | SD | Mean conc. (µg/mL) | SD | Mean conc. (µg/mL) | SD | Mean conc. (µg/mL) | SD |
0.5 | 5.098 | 0.467 | 16.841 | 1.508 | 47.606 | 1.148 | 77.532 | 20.593 | 75.982 | 26.49 | 68.228 | 18.95 |
1.5 | 1.272 | 0.339 | 6.856 | 0.844 | 18.278 | 7.101 | 32.302 | 4.982 | 45.473 | 12.494 | 75.788 | 29.628 |
3 | 0.746 | 0.201 | 2.588 | 0.114 | 8.286 | 0.651 | 13.167 | 2.324 | 26.25 | 8.477 | 30.209 | 13.53 |
6 | 0.211 | 0.019 | 0.734 | 0.182 | 9.501 | 1.304 | 3.042 | 1.433 | 2.385 | 0.645 | 13.558 | 11.989 |
12 | 0.043 | 0.003 | 0.104 | 0.051 | 0.251 | 0.004 | 0.257 | 0.058 | 0.466 | 0.166 | 1.082 | 0.97 |
24 | 0.013 | 0.005 | 0.008 | 0.002 | 0.013 | 0.002 | 0.014 | 0.004 | 0.019 | 0.003 | 0.038 | 0.018 |
AUC | 30 mg/kg EBO SC | 100 mg/kg EBO SC | 200 mg/kg EBO SC | 300 mg/kg EBO SC | 400 mg/kg EBO SC | 600 mg/kg EBO SC | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Total Area | 7.234 | 27.1 | 110.4 | 124.9 | 168.9 | 267.8 | ||||||
Std. Error | 0.5164 | 1.294 | 7.85 | 12.83 | 22.59 | 54.57 | ||||||
95% CI | 6.222 to 8.246 | 24.56 to 29.63 | 95.00 to 125.8 | 99.71 to 150.0 | 124.7 to 213.2 | 160.8 to 374.7 | ||||||
AUC: MIC | 7.2 | 27.1 | 110.4 | 124.9 | 168.9 | 267.8 |
