Table 3 Epetraborole dose fractionation statistics.
From: Pharmacokinetics and in vivo efficacy of epetraborole against Burkholderia pseudomallei
Pre treatment | Ceftazidime 300mpk | EBO 600mpk QD | EBO 300mpk BID | EBO 200mpk TID | EBO 300mpk QD | EBO 150mpk BID | EBO 100mpk TID | EBO 100mpk QD | EBO 50mpk BID | EBO 33mpk TID | |
|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Log10 CFU | 7.2 | 6.2 | 4.6 | 5.0 | 4.2 | 4.5 | 5.3 | 4.3 | 5.6 | 6.1 | 6.3 |
SEM | 0.31 | 0.1 | 0.089 | 0.11 | 0.095 | 0.13 | 0.14 | 0.17 | 0.087 | 0.051 | 0.04 |
Log10 CFU Drop | 1.0 | 2.6 | 2.2 | 3.0 | 2.7 | 1.9 | 2.9 | 1.6 | 1.1 | 0.9 | |
ANOVA (p-value to pre treatment) | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | |
