Fig. 2

Variant Landscape of PRGs in Stroke. (A) Volcano plot illustrating DEGs between Stroke and normal tissues (blue: down-regulated DEGs; yellow: up-regulated DEGs; grey: unchanged genes). Points with labels indicate significant Differentially expressed genes (DEGs) with FDR < 0.05 and |log2FC| > 0.5. (B) Venn diagram for the identification of 50 PANoptosis-related DEGs. (C) Heatmap of differential analysis between Stroke and normal group. Blue indicates the normal cohort, yellow denotes the stroke cohort, blue squares represent low expression, and red squares signify high expression. (D) Protein-protein interaction (PPI) network of PANoptosis-related DEGs. Each node represents a protein, and the edges indicate experimentally validated interactions between them. (E-F) GO term & KEGG enrichment analyses were put to use for the PANoptosis-related DEGs. The Y-axis represents enriched pathways, and the X-axis represents the gene ratio. The size of the bubble indicates the number of genes enriched in the term, and the color corresponds to the adjusted P-value.