Table 3 Changes in lung function (mL/y) for 6 years per every 10% change of PRMemph and PRMfSAD from baseline by GOLD classification at the baseline.

From: Longitudinal parametric response mapping on CT in assessing functional small airway disease and emphysema in COPD

Crude

PRMemph

FVC change

P

FEV1 change

P

All (n = 106)

30.2 (− 9.1, 69.4)

0.13

−6.2 (− 29.9, 17.6)

0.608

GOLD 1 (n = 63)

2.5 (− 61.6, 66.6)

0.937

3.0 (− 38.3, 44.3)

0.884

GOLD 2 (n = 43)

38.3 (− 10.4, 86.9)

0.119

−11.2 (− 38.6, 16.2)

0.413

PRMfSAD

FVC change

P

FEV1 change

P

All (n = 106)

−9.0 (− 15.5, − 2.4)

0.008

−6.0 (− 9.9, − 2.2)

0.003

GOLD 1 (n = 63)

−4.0 (− 10.9, 2.9)

0.249

−3.9 (− 8.3, 0.1)

0.083

GOLD 2 (n = 43)

−16.7 (− 28.6, − 4.9)

0.006

−8.9 (− 15.5, − 2.5)

0.008

Adjusted

PRMemph

FVC change

P

FEV1 change

P

All (n = 106)

22.9 (− 16.1, 61.9)

0.247

−6.7 (− 29.1, 15.7)

0.553

GOLD 1 (n = 63)

−3.6 (− 68.9, 61.8)

0.913

−1.5 (− 15.1, 42.1)

0.944

GOLD 2 (n = 43)

39.5 (− 18.1, 97.0)

0.172

−1.9 (− 30.7, 26.9)

0.895

PRMfSAD

FVC change

P

FEV1 change

P

All (n = 106)

−8.0 (− 14.5, − 1.6)

0.016

−6.0 (− 9.6, − 2.4)

0.001

GOLD 1 (n = 63)

−5.6 (− 12.7, 1.5)

0.119

−4.2 (− 8.9, 0.4)

0.074

GOLD 2 (n = 43)

−26.6 (− 40.8, − 12.4)

< 0.001

−11.8 (− 18.9, − 4.7)

0.002

  1. *Adjusted for age, sex, BMI, smoking, FEV1%pred at baseline, and inhaler therapy at baseline.
  2. FVC = forced vital capacity; FEV1 = forced expiratory volume in 1 s; %pred = % of the predicted value; emph = emphysema; fSAD = functional small airway disease; BMI = body mass index.
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