Fig. 3
From: A de novo FBN1 variant likely causes congenital bilateral ectopia lentis in a crossbred horse
Protein modelling of human fibrillin-1 domains with equine fibrillin − 1 XP_023473664.1:p.(Ala882Val). Structural alignment of the high-resolution crystal structure of human fibrillin-1 domains cbEGF9-hyb2-cbEGF10 (pdb code: 2W86) in blue with the AlphaFold3 model of the homologous Equus fibrillin-1 domains in green (RMSD: 0.995 Å over all C-α atoms). Disulfide bonds are shown in yellow. The red octagons show the Van der Waals clashes between Val-822 and the nearby disulfide bond.
