Fig. 2 | Scientific Reports

Fig. 2

From: Flagellin co-expression potentiates mRNA vaccine-induced cytotoxic T lymphocyte responses but not anti-tumor immunity

Fig. 2

FljB co-expression potentiates Th2-biased IgG1 antibody responses. (A). Illustration of experimental schedules. Note: mice in empty LNP group were euthanized on day 59 and one mouse in OVA mRNA group was euthanized on day 62 due to reaching humane endpoint. All other mice were euthanized on day 64. (B). OVA-specific IgG (left) and subtype IgG1 (middle) and IgG2c antibody responses (right) after prime. (C). FljB-specific IgG antibody responses after prime. D-E. Serum IL-6 levels 3, 24, and 48 h after prime (D) or boost (E). Two-way ANOVA with Dunnett’s multiple comparison test was used to compare differences of other groups with OVA mRNA group in B-E. n = 5. *, p < 0.05; **, p < 0.01; ***, p < 0.001. NS, not significant.

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