Table 3 Expression profiles of plasma MicroRNAs (miRNAs) significantly upregulated in patients with medication-related osteonecrosis of the jaw (MRONJ) compared to controls using qPCR array plates.

From: Comprehensive profiling of plasma and exosomal microRNAs in medication-related osteonecrosis of the jaw

Gene

P-value*

Q-value*

FC┼ (MRONJ/CON)

95% CI low

95% CI high

miR-153-3p

0.041

0.697

14.119

1.180

168.888

miR-1180-3p

0.025

0.697

9.559

1.476

61.916

miR-483-5p

0.015

0.697

8.935

1.794

44.494

miR-511-5p

0.031

0.697

8.194

1.374

48.876

miR-628-3p

0.032

0.697

5.424

1.247

23.588

miR-486-5p

0.048

0.697

5.236

1.017

26.965

miR-92b-5p

0.043

0.697

4.993

1.077

23.163

miR-500a-3p

0.031

0.697

3.385

1.159

9.892

miR-9-3p

0.043

0.697

3.084

1.047

9.087

let-7b-3p

0.007

0.697

2.856

1.513

5.390

let-7e-5p

0.033

0.697

2.374

1.092

5.158

  1. FC, fold change; CON, control; CI, confidence interval.
  2. *Differentially abundant miRNAs were determined using the Wilcoxon rank-sum test, with correction for multiple testing performed using the Benjamini–Hochberg (BH) method. Statistical significance was determined as a p-value < 0.05.
  3. ┼The FC value of each gene represents how many times the mean expression level in the MRONJ group is compared to the mean expression level in the control group. The 95% CIs of FC values were calculated. Only genes with a fold change (FC) of ≥ 2 were selected as targets for the subsequent experiments.
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