Fig. 3

Analysis of differentially expressed genes and immune cell ratio in the transcriptome data of AR. (A) PCA analysis of two sets of samples from AR PBMC transcriptome sequencing data (SRP548490). (B) Volcano plots demonstrating differentially expressed genes in the two sets of samples. (C) GO enrichment analysis of up-regulated and down-regulated differentially expressed genes. (D) GSEA results demonstrating significantly enriched biological pathways such as allograft rejection, inflammatory response and IFN-α response in the AR group. (E) Changes in the proportion of immune cells in samples from both groups.