Fig. 1 | Scientific Reports

Fig. 1

From: Peritoneal delivery of capsinoids, nonpungent TRPV1 agonists, induces mild hypothermia in conscious mice through TRPV1 activation of visceral vagal afferents

Fig. 1

Capsinoids induce an administration- and TRPV1-dependent hypothermia in young mice. a: Chemical structures of capsaicinoids and capsinoids. Black arrows represent amide groups and red arrows represent ester groups. b: Decrease in body temperature (Tb) in young male mice due to IP administration of DHC (2 mg/kg) and capsinoids (40 mg/kg) compared to vehicle. c: Tb does not change after OG administration of capsinoids. d: SC administration of capsinoids (40 mg/kg) does not alter Tb compared to vehicle control. e: SC administration of DHC (2 mg/kg) to same mice as in panel d elicits a drop in Tb. f: Capsinoid-induced hypothermia is TRPV1 dependent. (*: p < 0.05, **: p < 0.01, all drug administration points indicated by blue dashed lines).

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