Table 2 Biodistribution of the 64+67Cu-ODDA complex in tumor-bearing mice at various time points.

From: Radiolabeling and evaluation of 64+67Cu-2,2’-(1,2,4-Oxadiazole-3,5-diyl)di aniline as a theranostic agent for solid tumors

Organ/tissue

0.5 h p.i

1 h p.i

2 h p.i

4 h p.i

12 h p.i

24 h p.i

Tumor

(Right Thigh)

7.8 ± 0.4

13.5 ± 1.1

18.0 ± 0.3

7.8 ± 0.7

4.5 ± 0.4

2.1 ± 0.2

Left Muscle (Control Thigh)

1.4 ± 0.2

2.2 ± 0.3

1.9 ± 0.2

0.9 ± 0.2

0.6 ± 0.3

0.3 ± 0.1

Liver

6.0 ± 0.7

5.5 ± 0.6

4.8 ± 0.5

3.9 ± 0.4

2.8 ± 0.3

1.9 ± 0.2

Kidneys

10.5 ± 0.8

11.2 ± 0.7

10.8 ± 0.6

9.6 ± 0.5

7.4 ± 0.4

5.1 ± 0.3

Lungs

5.8 ± 0.5

4.9 ± 0.4

4.0 ± 0.4

3.1 ± 0.3

2.2 ± 0.2

1.5 ± 0.2

Spleen

2.4 ± 0.3

2.2 ± 0.3

2.0 ± 0.2

1.7 ± 0.2

1.2 ± 0.2

0.8 ± 0.1

Heart

2.0 ± 0.3

1.8 ± 0.3

1.6 ± 0.2

1.3 ± 0.2

1.0 ± 0.2

0.6 ± 0.1

Bone

2.5 ± 0.3

2.3 ± 0.2

2.0 ± 0.2

1.6 ± 0.2

1.3 ± 0.2

1.0 ± 0.2

Intestine

2.8 ± 0.4

2.5 ± 0.3

2.2 ± 0.3

1.9 ± 0.2

1.4 ± 0.2

0.9 ± 0.1

Blood

4.0 ± 0.5

3.5 ± 0.4

3.0 ± 0.3

2.4 ± 0.3

1.8 ± 0.2

1.0 ± 0.2

T/NT

5.6

6.1

9.4

8.6

7.5

7.0

Tumor/Blood

1.9

3.9

6.0

3.3

2.5

2.1