Fig. 1 | Scientific Reports

Fig. 1

From: Rutin ameliorates sevoflurane-induced neurotoxicity by inhibiting microglial synaptic phagocytosis through the complement pathway

Fig. 1

Rutin alleviated cognition dysfunction in sevoflurane-treated mice. (A) Scheme of repeated neonatal sevoflurane exposures and the behavioral test in mice (B) The OF test. Representative tracking path of mice in the four groups. (C) Analysis of the number of entries into the center zoom, times spent in the center zoom, and central distance traveled in the four groups of mice. (n = 12). (D) MWM test. representative swimming path of mice in the four groups. (E) Rutin reduced the escape latency compared to treatment with sevoflurane and PBS. (n = 12). (F) Rutin increased platform cross times and time spent in the target quadrant compared to treatment with sevoflurane and PBS. (n = 12). One‑way ANOVA or Two-way ANOVA followed by a post hoc Tukey’s test was used for comparisons between the multiple groups. Data were presented as the mean ± SEM. * P < 0.05, ** P < 0.01, *** P < 0.001.

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