Table 1 Mean particle sizes, span, and particle concentrations of mRNA-LNP samples with no shaking, after 30 min of shaking, and after 240 min.
From: Elucidating the underlying mechanism of mechanical stress-induced impact on mRNA-LNP structure
Shaking time | Mean diameter (nm) | Span | Particle concentration (particles/mL) |
|---|---|---|---|
No shaking | 50.6 (0.57) | 0.49 (0.07) | 2.54e + 13 (2.80e + 12) |
30 min | 52.0 (0.87) | 0.51 (0.08) | 1.84e + 13 (1.60e + 12) |
240 min | 84.6 (1.04) | 0.87 (0.13) | 6.81e + 12 (5.77e + 11) |
