Table 1 Characterization of p-blinatumomab and BLINCYTO.
Protein | Expression Yield | Binding affinity (Kd) in ELISA | Binding affinity (Kd) in FCM | Molecular weight | ||
|---|---|---|---|---|---|---|
p-blinatumomab | 1.2 mg/L | CD19 | 11.7 nM; | CD19 | 10.7 nM | 54,250 Da |
CD3ɛ | 20.6 nM | CD3ɛ | 97.7 nM | |||
BLINCYTO | N/A | CD19 | 21.8 nM | CD19 | 10.2 nM | 54,100 Da |
CD3ɛ | 29.6 nM | CD3ɛ | 105.1 nM | |||
