Table 6 Prediction of toxicity profiles of two selected lead compounds along with the reference compound using the PkCSM and ADMET SAR web servers.
Compound name | hERG inhibitor | LD50 of rat (Mol/kg ) | AMES test | Carcinogens | Acute oral toxicity | Skin sensitization |
|---|---|---|---|---|---|---|
6-Hydroxyluteoli | Weak inhibitor | 3.0200 | No | No | II | No |
Isorhamnetin | Weak inhibitor | 2.7192 | No | No | III | No |
Sunitinib (Control) | Weak Inhibitor | 2.6794 | No | No | III | No |
