Fig. 2 | Scientific Reports

Fig. 2

From: Evaluation of (Z)-endoxifen as a potential therapy for glioblastoma multiforme through computational and experimental analyses

Fig. 2The alternative text for this image may have been generated using AI.

(A) Analysis of genes intersecting between bulk GBM and endoxifen data. The red arrow pointing up and the blue arrow pointing down describe a group of genes that were upregulated in GBM and downregulated by endoxifen in MCF7 cells. The red arrow pointing down and the blue arrow pointing up describe a group of genes that were downregulated in GBM and upregulated by endoxifen in MCF7 cells. (B) GSEA analysis for 560 genes upregulated in GBM and downregulated after endoxifen treatment in MCF7 cells. Ranking is based on adjusted p-value. Coloring is based on Combined score =  − log(p-value) * Odds Ratio. Dot size is based on the number of genes related to the pathway. All significant hallmarks are presented.

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