Fig. 5 | Scientific Reports

Fig. 5

From: Evaluation of (Z)-endoxifen as a potential therapy for glioblastoma multiforme through computational and experimental analyses

Fig. 5The alternative text for this image may have been generated using AI.Fig. 5The alternative text for this image may have been generated using AI.Fig. 5The alternative text for this image may have been generated using AI.

Results of the analysis of the genes associated with a patient’s survival and GBM subtypes. (A) Kaplan–Meier survival analysis based on the TCGA-GBM dataset. Heatmaps based on PandaOmics expression analysis in GBM (B) and (E) endoxifen meta-analyses. (C) UMAPs of HSPB1, PRA3 and NFKBIZ expression in GBM samples from GSE84465 scRNA-seq. (D) Boxplots for HSPB1, PRA3 and NFKBIZ genes from GSE84465 scRNA-seq GBM study. (F) UMAPs and boxplot of HSPB1 expression in GBM samples with Mesenchymal (MES) and Proneural/Classical (PN&CL) subtypes based on GSE159416 scRNA-seq GBM study. *p-value < 0.05, **p-value < 0.01, ***p-value < 0.0001.

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