Fig. 4 | Scientific Reports

Fig. 4

From: Correction: Network pharmacology uncovers that secoisolariciresinol diglucoside ameliorate premature ovarian insufficiency via PI3K/Akt pathway

Fig. 4The alternative text for this image may have been generated using AI.

SDG counters CTX-induced toxicity in granulosa cells via PI3K/Akt pathway modulation. (A) The cell viability of KGN treated with different concentrations of CTX. (B) The cell viability of KGN treated with different concentrations of SDG and 500 μm CTX. (C–F) The expression levels of PI3K/Akt pathway proteins in KGN cells after treatment with 500 μm CTX or co-treatment with 500 μm CTX and 400 μm SDG. (G) The microscopic morphology of KGN cells after treatment with 500 μm CTX or co-treatment with 500 μm CTX and 400 μm SDG. Statistical significance: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 versus control. #p < 0.05, ##p < 0.01, ###p < 0.001 versus CTX group.

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