Fig. 4
From: Targeting KRASG13C with cyclic linker based inhibitors to explore warhead orientation
Novel nucleotide-based inhibitors modify KRASG13C covalently. (A): pH-dependent covalent modification of KRASG13C1−169 (Cys-light) proteins at pH 7.5–9.5 after 24 h at rt (the graph was prepared in Excel). (B): Time-dependent analysis of the covalent modification of KRASG13C1−169 (Cys-light) at pH 9.5 and rt.
