Fig. 6 | Scientific Reports

Fig. 6

From: Computational and pharmacophore-based study of Camellia sinensis phytochemicals targeting BRAF in melanoma

Fig. 6Fig. 6

Graphs illustrate the RMSD values of the BRAF protein (PDB ID: 4MNF) and four ligands over 200 ns simulation run. (A) BRAF-epicatechin gallate, (B) BRAF-plixorafenib (control), (C) BRAF-epigallocatechin 3-0- cinnamate, and (D) BRAF-theaflagallin complexes. The X-axis on the left indicates protein RMSD while the Y-axis on the right indicates ligand RMSD value. Blue lines show total BRAF RMSD; orange, green, red, and purple lines represent RMSD values of all heavy atoms, backbone, Cα atoms, and sidechains, respectively, were generated by RStudio Version: 2025.05.1-513 (https://posit.co/download/rstudio-desktop/).

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