Fig. 8 | Scientific Reports

Fig. 8

From: Computational and pharmacophore-based study of Camellia sinensis phytochemicals targeting BRAF in melanoma

Fig. 8

Graphs represent the Root Mean Square Fluctuation (RMSF) analysis of BRAF protein residues bound to various ligands over a 200 ns MD simulation and figure was generated by RStudio Version: 2025.05.1-513 (https://posit.co/download/rstudio-desktop/). The graph compares the atomic fluctuations of residues for complexes with Epicatechin gallate (green), Epigallocatechin 3-O-cinnamate (black), Theaflagallin (purple), and Plixorafenib (red, control). Notable residue fluctuations are annotated, particularly around residues 624–633, which indicate significant ligand-induced dynamic changes.

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