Table 4 Prediction of toxicity profile analysis of reported three compounds through ProTox-II server.
Toxicity properties prediction | ||||
|---|---|---|---|---|
Ames Toxicity | No | No | No | No |
hERG Ⅰ Inhibitor | No | No | No | No |
hERG Ⅱ Inhibitor | Yes | Yes | Yes | Yes |
Rat Acute Toxicity (LD50, mol/kg) | 2.559 | 2.67 | 2.558 | |
Oral Toxicity Classification* | Ⅳ | Ⅳ | Ⅳ | Ⅲ |
Hepatotoxicity | No | No | No | Yes |
Nephrotoxicity | No | No | No | No |
Skin Sensitization | No | No | No | No |
Cytotoxicity | Inactive | Inactive | Inactive | Inactive |
Carcinogenicity | Inactive | Inactive | Inactive | Inactive |
Immunotoxicity | Inactive | Inactive | Inactive | Inactive |
Mutagenicity | Inactive | Inactive | Inactive | Inactive |
P-glycoprotein inhibitor | No | Yes | No | Yes |
hERG blockage | Non-blocker | Non-blocker | Non-blocker | Non-blocker |
