Table 2 Statistical performance of HMMGB1 at fixed specificities for each diagnostic test.

From: Diagnostic utility of high-mobility group box 1 for acute exacerbations of idiopathic pulmonary fibrosis

Diagnostic method

Sensitivity

Specificity

95% confidence intervals

HMGB1 [ng/mL] cutoff value*

Test-1

0.80

0.508

(0.330, 0.753)

4.15

0.85

0.449

(0.275, 0.703)

3.65

0.90

0.322

(0.117, 0.616)

2.85

0.95

0.229

(0.076, 0.468)

2.25

Test-2

0.80

0.647

(0.215, 0.749)

1.1

0.85

0.472

(0.240, 0.781)

0.05

0.90

0.259

(0.299, 0.808)

−1.5

0.95

0.239

(0.530, 0.916)

−1.8

Test-3

0.80

0.574

(0.419, 0.825)

0.5

0.85

0.521

(0.368, 0.737)

0.15

0.90

0.398

(0.109, 0.623)

−0.5

0.95

0.124

(0.086, 0.535)

−3.4

Test-4

0.80

0.919

(0.293, 0.989)

1.05

0.85

0.919

(0.145, 0.978)

1.02

0.90

0.318

(0.000, 0.959)

−0.19

0.95

0.156

(0.000, 0.926)

−0.43

  1. The cutoff value is used to determine the threshold for diagnosis. However, this is not a fixed value, and the results May vary across different clinical settings and patient populations. Therefore, each diagnostic test should be adapted to the specific clinical situation and adjusted accordingly.
  2. HMGB1, high-mobility group box 1.
  3. Cutoff values can be negative in Test-2 to Test-4, because the differences in the HMGB1 levels, not the value itself, were adopted in those tests.
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