Fig. 2

Characterization of the intestine-liver-on-a-chip. (A) Immunostaining analysis of Zo-1 (green) and CYP2D6 (red) was performed in the WT and genome-edited intestine-liver-on-a-chip. Nuclei were stained with DAPI (blue). Scale bars represent 100 μm. (B) Apical-to-basolateral permeability of 100 μM LY across the intestine-liver-on-a- intestine-liver-on-a-chip was measured. Data represent the means ± SDs (n = 3 devices).