Table 4 Mediation effect of ePWV (continuous variable) on the association between PA levels and CVD risk (n = 10,055).

From: Mediating role of arterial stiffness in the association between physical activity and cardiovascular disease risk: a prospective cohort study

 

Crude model

Model 1

Model 2

HR (95% CI)

value

HR (95% CI)

value

HR (95% CI)

value

Exposure: Moderate PA (ref. high PA)

TE

1.515 (1.264,1.791)

< 0.001

1.268 (1.051,1.515)

0.008

1.251 (1.063,1.500)

0.024

NIE

1.262 (1.207,1.320)

< 0.001

1.089 (1.062,1.121)

< 0.001

1.060 (1.038,1.088)

< 0.001

NDE

1.200 (0.993,1.417)

0.056

1.164 (0.966,1.384)

0.104

1.180 (0.995,1.420)

0.064

PM

0.612 (0.443,1.025)

< 0.001

0.389 (0.212,1.451)

0.008

0.281 (0.121,0.897)

0.024

Exposure: Low PA (ref. high PA)

TE

3.289 (2.048,4.809)

< 0.001

2.395 (1.510,3.648)

< 0.001

2.230 (1.383,3.498)

0.008

NIE

1.462 (1.310,1.644)

< 0.001

1.150 (1.078,1.242)

< 0.001

1.096 (1.042,1.167)

< 0.001

NDE

2.249 (1.403,3.301)

0.004

2.084 (1.294,3.191)

0.004

2.035 (1.265,3.205)

0.008

PM

0.454 (0.330,0.642)

< 0.001

0.223 (0.120,0.433)

< 0.001

0.159 (0.073,0.340)

0.008

Exposure: Low/moderate PA (ref. high PA)

TE

1.617 (1.350,1.916)

< 0.001

1.336 (1.106,1.601)

< 0.001

1.310 (1.110,1.565)

0.004

NIE

1.275 (1.219,1.329)

< 0.001

1.094 (1.069,1.125)

< 0.001

1.064 (1.042,1.093)

< 0.001

NDE

1.269 (1.061,1.505)

0.004

1.221 (1.021,1.452)

0.032

1.231 (1.046,1.471)

0.024

PM

0.565 (0.425,0.830)

< 0.001

0.341 (0.202,0.831)

< 0.001

0.255 (0.134,0.595)

0.004

  1. Mediator was continuous value of ePWV.
  2. 95% CI, 95% confidence interval; HR, hazard ratio; NDE, natural direct effect; NIE, natural indirect effect; PM, proportion mediated; TE, total effect.
  3. Model 1: adjusted for sex and age group.
  4. Model 2: adjust for sex; age group; marital status; education attainment; farmer; annual household income; current smoker; current drinker; sedentary time; BMI level; baseline pulse pressure; hypertension; diabetes mellitus; FBG; TC; HDL-C.