Fig. 5
From: Morphological alterations of peridroplet mitochondria in human liver biopsy
Relationship between clinical parameters and mitochondrial morphological descriptors. (a) Heatmap displaying maximal information coefficient (MIC) values that quantify the strength of association between clinical parameters (e.g., triglyceride levels, liver enzymes, cholesterol levels, steatosis grade) and morphological metrics of peridroplet (PDM) and cytoplasmic mitochondria (CM). MIC values range from 0 (no association) to 1 (perfect relationship), with lower values in blue and higher values in red. (b) Scatter plot illustrating a significant positive correlation between patient age and CM roundness (r = 0.3442, p = 0.0296), suggesting increased mitochondrial sphericity with aging. (c) Scatter plot showing a significant inverse correlation between patient age and CM aspect ratio (r = -0.3459, p = 0.0288), indicating age-associated mitochondrial fragmentation. CM, cytoplasmic mitochondria; MIC, maximal information coefficient; PDM, peridroplet mitochondria.
