Fig. 2

µCT imaging revealed age-dependent progression of airway mucus obstruction in βENaC-tg mice. Representative µCT reconstructions illustrating the age-dependent progression of airway mucus obstruction in βENaC-tg mice, compared to wild-type. Images show newborn, juvenile, and adult stages for both genotypes. Note the spontaneous formation and accumulation of mucus plugs in βENaC-tg mice from juvenile to adult stages, which is absent in wild-type mice. Red boxes mark regions magnified 3x. Scale bars are 1 mm. µCT = micro-computed tomography. wt = wild-type. βENaC-tg = βENaC-transgenic.