Fig. 4 | Scientific Reports

Fig. 4

From: Phosphoproteomic profiling highlights CDC42 and CDK2 as key players in the regulation of the TGF-β pathway in ALMS1 and BBS1 knockout models

Fig. 4

Protein–protein interaction analysis highlights CDK2 as the central node of the BBS1 interactome and CDC42EP3 as the central node of the ALMS1 interactome. Red nodes represent the DPP that were detected in the first analysis. Blue nodes represent the nodes inferred by RWR algorithm. (A) Interactome of the top 100 proteins with the highest RWR score after network diffusion in the BBS1KO. (B) Interactome of the top 100 proteins with the highest RWR score after network diffusion in the ALMS1KO.

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