Fig. 1

Signalling events during tail regeneration. (a) Larval tail excision removes the end of the zebrafish tail and includes different cell types. (b) Within 0.5 h post excision (hpe) early wound signals are released and the wound is closed. (c) The body axis shortens and the notochord bead is extruded. (d) The notochord bead becomes a HH signalling centre that activates regeneration. (e) Regenerative cells migrate towards the stump. (f) The wound epithelium and blastema form. (g) The tail reforms. (h and i) Models presented in this paper.