Table 3 In vitro combinate effect of the BD132 dendron and amphotericin B against C. albicans and N. glabratus in biofilm formed.

From: Antibiofilm activity of cationic carbosilane BD132 dendron and its synergistic effect with amphotericin B against Candida spp.

Effect of BD132 Dendron eradicanting biofilm formed (MBEC)

 

Individual (mg/L)

In combination (mg/L)

 

BD132

Amphotericin B

BD132

Amphotericin B

FICIa

C. albicans

256–512

NEB

64

2

< 0.5

8

2

< 0.5

N. glabratus

128

NEB

64

0.12

< 0.5

32

4

< 0.5

  1. NEB No Biofilm Eradication.
  2. aFICI ≤ 0.5: synergic activity. A biofilm eradication activity using amphotericin alone was not recorded (NEB). Therefore, the highest concentration tested of amphotericin (32 mg/L) was used to calculate the FICI values.
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