Table 2 Variables selected for the Cox proportional hazards regression model for overall survival.
Variable | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
Hazard ratio | 95% CI | P-value | Hazard ratio | 95% CI | P-value | ||
Age at the time of brain metastasis (years) | < 65 (younger) | 1.00 | (Reference) | 0.90 | 1.00 | (Reference) | 0.43 |
≥ 65 (elder) | 1.03 | (0.67–1.60) | 1.21 | (0.75–1.92) | |||
Karnofsky performance status | ≥ 70 | 1.00 | (Reference) | 0.29 | 1.00 | (Reference) | 0.03* |
< 70 | 1.27 | (0.82–1.96) | 1.64 | (1.05–2.60) | |||
Presence of extracranial metastases | No (brain only) | 1.00 | (Reference) | 0.10 | 1.00 | (reference) | 0.56 |
Yes (brain and other sites) | 1.57 | (0.93–2.86) | 1.22 | (0.66–2.34) | |||
Control of primary tumor | Controlled | 1.00 | (Reference) | 0.36 | 1.00 | (Reference) | 0.17 |
Uncontrolled | 1.30 | (0.68–2.46) | 1.61 | (0.78–3.07) | |||
Brain metastases, n | 1 | 1.00 | (Reference) | 0.04* | 1.00 | (Reference) | 0.02* |
2 | 1.43 | (0.71–2.73) | 2.23 | (1.01–4.86) | |||
3 | 2.05 | (0.82–4.47) | 2.01 | (0.76–4.75) | |||
extensive (> 3) | 2.00 | (1.22–3.31) | 2.13 | (1.18–3.91) | |||
Maximum diameter of brain lesion* | 0.23 | (0.16–1.10) | 0.08 | 0.99 | (0.98–1.00) | 0.33 | |
History of systemic chemotherapy before brain metastases* | 1.43 | (1.22–1.67) | < 0.01 | 1.39 | (1.16–1.67) | < 0.01 | |
