Fig. 2 | Scientific Reports

Fig. 2

From: CRISPR/Cas9-mediated deletion of MADD induces cell cycle arrest and apoptosis in anaplastic thyroid cancer cells

Fig. 2

MADD gene deletion leads to transcriptomic changes in ATC cell lines: (A) Kaplan-Meier curve demonstrates the association of MADD mRNA expression levels in thyroid cancer patients with the overall survival rate in the TCGA database. High MADD expression correlates with shorter overall survival Shaded areas represent 95% confidence intervals, timeline in days (X-axis). (B) Venn diagrams showing the overlap of up-regulated (left) and down-regulated (right) genes among 8505 C, C643, and HTH7 cell lines following MADD deletion. (C) Gene Ontology (GO) based enrichment analysis of differentially expressed genes (DEGs) of MADD knockout and control cells. (D) GO enrichment analysis of differentially expressed genes related to cell cycle, proliferation, migration, and apoptosis. The bar graph shows the gene count for each GO term.

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