Fig. 2

Box plots of methylation levels of targeted CpGs and LINE-1 (global methylation) at 3 different time points: prior to CBCT, one month after CBCT, and one year after start of CBCT. The box plots are sorted by methylation status. Top 7 CpGs were significant for difference in methylation between prior to CBCT and one year after start of CBCT. Significance marked as: ***= p ≤ 0.001, *= p ≤ 0.05. CBCT = cisplatin-based chemotherapy; +1 M = one month after CBCT; + 1Y = one year after start of CBCT.