Fig. 1

The core eMI machinery is present and expressed in Oncorhynchus mykiss (RT, rainbow trout) tissues and the RT-derived RTH-149 cells. (A) Schematic representation of the evolutionary history of RT genes showing the third round of genome duplication (Ts3R) experienced by teleost fish, and the additional round of whole-genome duplication (Ss4R) of salmonids. (B) Identification (Ensembl ID) and chromosome location (Chr) of the main eMI-genes (TSG101, VPS4A, VPS4B, ALIX and BAG6) in the human genome, and their corresponding RT orthologs. (C) Heat map showing mRNA expression levels (TPM, transcripts per million) of the different identified genes in different tissues of RT (brain, gills, heart, muscle, liver, kidney, bones, intestine and ovary) extracted from the RNA-Seq database PhyloFish, as well as in RTH-149 cells (framed with red line) analyzed by BRB-Seq in the current work.