Fig. 8 | Scientific Reports

Fig. 8

From: HMGB1 mediated autophagy and apoptosis in human nucleus pulposus cells; chloroquine amplified apoptosis by inhibiting autophagy

Fig. 8

Nutrient deprivation increased cleaved caspase-3 expression in a manner proportional to the level of deprivation, with a peak observed at 48 h under 0% FBS conditions. While CQ treatment combined with serum deprivation elevated cleaved caspase-3 expression by 2- to 3-fold compared to serum deprivation alone, also peaking at 48 h under 0% FBS (n = 4 with level of significance *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001).

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