Table 2 Changes in kidney profile of the control group and experimental groups treated with Ivermectin alone or in combination with folic acid and/or vitamin B12 in adult male albino rats.

From: Ameliorative effect of folic acid and vitamin B12 against Ivermectin-induced hepatotoxicity, renal toxicity, oxidative stress and immunohistochemical changes in male albino rats

Parameters

Creatinine (mg/dl)

Urea (mg/dl)

BUN (mg/dl)

UA (mg/dl)

Ctrl group

0.46 ± 0.11b

35.17 ± 02c

19.57 ± 4.79b

2.1 ± 0.12b

IVM group

1.2 ± 0.1a

134.5 ± 6.5a

49.25 ± 13.9a

3.4 ± 0.45a

IVM + FA group

0.71 ± 0.1b

50.33 ± 2.7c

24.20 ± 2.9b

2.5 ± 0.5b

IVM + Vit. B12 group

0.54 ± 0.04b

90.00 ± 4.3b

47.29 ± 9.6a

3.1± 0.19a

  1. Values are means ± S.D. Values with different superscript (a, b and c) in the same column are significantly different at P < 0.05. Ctrl group: Control group; IVM group: Ivermectin group; IVM + FA group: Ivermectin + Folic acid group; IVM + Vit. B12 group: Ivermectin + Vit. B12 group; BUN: Blood urea nitrogen; UA: Uric acid.