Table 6 Quantitative analysis of integrated density (IntDen) values for Caspase-3, Bcl-2-associated X-protein (BAX), B-cell lymphoma 2(Bcl-2) and proliferating cell nuclear antigen (PCNA) expressions in the kidney tissues (Mean ± S.D).

From: Ameliorative effect of folic acid and vitamin B12 against Ivermectin-induced hepatotoxicity, renal toxicity, oxidative stress and immunohistochemical changes in male albino rats

Tissues

Parameters

Ctrl-group

IVM-group

IVM + FA

IVM + Vit.B12

Kidney

Caspase-3

22.68 ± 1.6b

78.76 ± 4a

48.9 ± 15.14b

50.84 ± 9.2b

BAX

4.46 ± 1.3b

97.40 ± 11a

11.68 ± 2.6b

12.27 ± 2.8b

Bcl-2

112.6 ± 5.3a

20.20 ± 1.3b

97.46 ± 2.3a

143.2 + 6.4a

PCNA

478.5 ± 3.4a

339.3 ± 8.5b

459.7 ± 4.9a

612.1 ± 0.05a

  1. Values bearing different superscripts (a & b) in the same row differ significantly (P < 0.05).
  2. Ctrl-group: control group, IVM group: Ivermectin group; IVM + FA: Ivermectin + Folic acid group, IVM + Vit.B12: Ivermectin + Vitamin B12 group.
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