Fig. 3
From: Quantifying cancer- and drug-induced changes in Shannon information capacity of RTK signaling
Bitrate of individual cells. (A) Histograms of the bitrates of individual cells; for each condition, all the biological and technical replicates are pooled. The cells are divided into transmitting and non-transmitting subpopulations so that the average bitrate in the non-transmitting subpopulation is zero. The dotted lines show the bitrate averaged over non-transmitting (red), transmitting (green), and all cells (yellow). (B) Fractions of transmitting cells computed for each replicate separately; average and standard error of the mean are shown. (C) Average bitrate in the transmitting cell subpopulation computed for each replicate separately; average and standard error of the mean are shown; the dotted line indicates the input information rate. (D) Bitrate vs. average response amplitude in individual cells; the dot intensity is proportional to the time for which each cell was tracked. In panels B and C, dots correspond to experimental replicates; dots of the same color denote results from the same experiment. The threshold shown in panel A (blue line) was computed for all replicates pooled, whereas in panels B and C, the threshold was chosen for each replicate separately.
