Fig. 2

Transcriptome analysis of TCL1 mice. (A) Principle component analysis of transcriptome analysis from IGHV11 (n = 9) and IGHV1 (n = 4) mice from sorted CD5⁺CD19⁺ splenocytes. (B) Volcano plot indicating differentially expressed genes of IGHV11 (n = 9) and IGHV1 (n = 4) mice from sorted CD5⁺CD19⁺ splenocytes. Genes up- or downregulated with a fold change ≥ 2 and an FDR < 0.05 are depicted in red. (C) Enriched MSigDB Hallmark pathways between IGHV11 (n = 9) and IGHV1 (n = 4) mice from sorted CD5⁺CD19⁺ splenocytes. Only significantly enriched pathways are depicted (padj. < 0.05). (D) Gene set enrichment analysis of three gene sets, each tested IGHV11 versus IGHV1. B1a and B2 specific gene sets were defined by Mabbot et al.¹⁵. IgH-TEµ CLL B1a gene set was published by Singh et al.¹⁶.