Fig. 4 | Scientific Reports

Fig. 4

From: IGHV1 usage is associated with lymphadenopathy and aggressive disease in the TCL1 mouse model for chronic lymphocytic leukemia

Fig. 4

LN migration of IGHV11 and IGHV1 clones. (A) Paired dot plot comparing the dominant clone of matched SPL (n = 18; IGHV11 n = 9; IGHV1 n = 9) and LN (n = 18) samples. (B) Representative pictures of LNs from mice with a dominant IGHV11 (ID: 813) and IGHV1 (ID: 537) clone. (C) Dot plot comparing LN size, and dominant clone in SPL and LN of mice with analysed LN B-cell repertoire of IGHV11 (n = 9) and IGHV1 (n = 8, LN size of one mouse not measurable). (D) Dot plot displaying LN size based on BCR repertoire of LN if available or the initially sequenced organ of IGHV11 (n = 25) and IGHV1 (n = 25) mice. Wilcoxon test was used to compare IGHV11 and IGHV1 data.

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