Fig. 6
Potential mechanism of B1 asRNA action in enhancing the function of spleen lymphocytes from aged BALB/c mice. (A) In mice, B1 RNA level increases with thecell aging process due to transcription of B1 elements by RNA polymerase III. (B) Increased B1 RNA can bind to the inhibitory proteins to form RNA-protein complexes, which prevents the ZFP92 gene transcription. (C) When B1 asRNA was transfected into lymphocytes, B1 asRNA could bind to B1 RNA, which alleviated the inhibition effect of B1 RNA on ZFP92 gene transcription, thus increasing the expression of ZFP92 protein. (D) ZFP92 protein can bind to B1 elements in the transcription factor genes and its upstream and downstream sequences, resulting in increased expression of transcription factor genes.
