Table 2 Subgroup analyse of OBI in HBcAb-positive population.

From: Global prevalence of occult hepatitis B virus infection in HBcAb-positive individuals: a systematic review and meta-analysis

Subgroups

Study(n)

Pooled estimates of OBI (95% CI)

Heterogeneity

(I2%)

P-value

HBV prevalence

   

P = 0.05

Low-endemic regions

18

3% (1, 7%)

97%

 

Intermediate/high-endemic regions

24

10% (4, 18%)

98%

 

HBcAb-positive rate

   

P = 0.05

[0, 10) %

12

2% (0, 5%)

97%

 

[10, 30) %

14

7% (2, 13%)

97%

 

[30, 100) %

14

13% (4, 25%)

97%

 

Detection method

   

P = 0.17

Nested PCR

13

9% (4, 17%)

96%

 

Real-time qPCR

23

5%(2, 8%)

97%

 

HBsAb status

   

P = 0.96

HBsAb-positive

22

8%(3, 16%)

97%

 

HBsAb-negative

22

8%(3, 16%)

95%

 

Year of publication

   

P = 0.44

2000–2010

13

9% (3, 19%)

98%

 

2011–2015

13

8% (1, 19%)

97%

 

2016–2024

16

4% (2, 8%)

97%

 

Population

   

P = 0.82

Blood donors

30

6% (3, 11%)

98%

 

Other general population

12

7% (2, 16%)

96%