Table 3 Subgroup analyse of OBI in HBcAb-negative population.

From: Global prevalence of occult hepatitis B virus infection in HBcAb-positive individuals: a systematic review and meta-analysis

Subgroups

Study(n)

Pooled estimates of OBI (95% CI)

Heterogeneity

(I2%)

P-value

HBV prevalence

   

P = 0.30

Low-endemic regions

3

1% (0, 4%)

79%

 

Intermediate/high-endemic regions

11

2% (0, 6%)

93%

 

HBcAb-positive rate

   

P < 0.01

[0, 10) %

1

0% (0, 1%)

-

 

[10, 30) %

6

2% (0, 4%)

93%

 

[30, 100) %

7

3% (0, 8%)

93%

 

Detection method

   

P = 0.11

Nested PCR

6

4% (0, 10%)

94%

 

Real-time qPCR

6

1%(0, 2%)

70%

 

HBsAb status

   

P = 0.91

HBsAb-positive

6

2%(0, 6%)

90%

 

HBsAb-negative

9

2%(0, 5%)

91%

 

Year of publication

   

P = 0.04

2000–2010

5

6% (2, 12%)

93%

 

2011–2015

4

0% (0, 2%)

77%

 

2016–2024

5

1% (0, 4%)

89%

 

Population

   

P = 0.39

Blood donors

5

1% (0, 4%)

89%

 

Other general population

9

3% (0, 6%)

93%