Table 3 Description and definition of outcome events in this cohort study.
Event | Event Description | Definition |
|---|---|---|
Index date | Dispensation date of PPI or H2B | Cohort entry begins at the index date |
CKD Outcomes Adverse outcomes related to chronic kidney disease | eGFR Decline | ≥ 30% decline from the index eGFR |
CKD Incidence | eGFR < 60 mL/min/1.73 m² | |
Kidney Replacement Therapy (KRT) | Dialysis or kidney transplantation, confirmed by the Swedish Renal Registry | |
Death due to CKD | Classified under ICD-10 code N18 | |
Cardiovascular Adverse Events (CVAE) Adverse cardiovascular events | Myocardial Infarction | Identified using ICD-10 codes recorded during inpatient visits: I21, I22 |
Heart Failure | Identified using ICD-10 codes recorded during inpatient visits: I099, I110, I130, I132, I255, I420, I425, I426, I527, I428, I429, I43, I50, P290 | |
Stroke | Identified using ICD-10 codes recorded during either inpatient visits: I60, I61, I63, I64 | |
Death due to Cardiovascular Events | Death attributed to cardiovascular causes defined by ICD-10 codes I21, I22, I099, I110, I130, I132, I255, I420, I425, I426, I527, I428, I429, I43, I50, P290, I60, I61, I63, I64 | |
Death | All-cause mortality, death from any cause | Recorded at any point during follow-up |
Study end | The date on which follow-up ended for participants who did not experience any events. | Follow-up ended on December 31, 2021, or on the date of emigration from Sweden, whichever occurred first |
