Fig. 2 | Scientific Reports

Fig. 2

From: The role of urine derived exosome metalloproteinases as biomarkers for prostate cancer detection may be confounded by non-malignant prostatic inflammation

Fig. 2

Tumor-specific fingerprinting of urinary MMP. (A) Zymograms of MMPs in representative urine samples from healthy subjects and PCa patients. (B) Positive expression of MMP-9 and MMP-2 in urine exosomes from healthy subjects and PCa patients. (C) Gelatinase species in urine of healthy subjects (upper panel) and PCa patients (lower panel). Representative urine samples were analyzed by zymography with their respective band profiles. Uncropped full-length gels corresponding to these panels, with membrane edges visible, are provided in Supplementary Fig. 1S. * P < 0.001 for each, Fisher’s exact test. MMP: matrix metalloproteinase; NGAL: neutrophil gelatinase-associated lipocalin.

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