Table 1 Basic information of pregnant women in the four groups(%).
Variable | Isolated CHD group | Non-isolated CHD group | Non-CHD group | Normal group | χ2/Fisher | P-Vale |
|---|---|---|---|---|---|---|
n | 237 | 136 | 1632 | 3111 | ||
Number of pregnancies | ||||||
1 | 93(39.24) | 45(33.09) | 564(34.56) | 674(21.66) | 131.61 | < 0.001 |
2 | 58(24.47) | 47(34.56) | 477(29.23) | 922(29.64) | ||
≥ 3 | 86(36.29) | 44(32.35) | 591(36.21) | 1515(48.70) | ||
Number of births | ||||||
0 | 133(56.12) | 68(50.00) | 791(48.47) | 1107(35.58) | 110.01 | < 0.001 |
1 | 93(39.24) | 55(40.44) | 711(43.57) | 1627(52.30) | ||
2 | 10(4.22) | 11(8.09) | 119(7.29) | 341(10.96) | ||
≥ 3 | 1(0.42) | 2(1.47) | 11(0.67) | 36(1.16) | ||
High risk factor | ||||||
Yes | 75(31.65) | 44(32.35) | 417(25.55) | 1996(64.16) | 688.108 | < 0.001 |
No | 162(68.35) | 92(67.65) | 1215(74.45) | 1115(35.84) | ||
Types of risk factors | ||||||
Advanced age | 43(18.14) | 24(17.65) | 324(19.85) | 1119(35.97) | 159.47 | < 0.001 |
History of adverse pregnancy | 37(15.61) | 18(13.24) | 76(4.66) | 563(18.10) | 165.81 | < 0.001 |
Noninvasive DNA is high risk | 7(2.95) | 7(5.15) | 63(3.86) | 667(21.44) | 306.28 | < 0.001 |
One of the couples has a chromosomal abnormality | 2(0.84) | 0(0.00) | 6(0.37) | 54(1.74) | 19.87 | < 0.001 |
Variable | Isolated CHD group | Non-isolated CHD group | Normal group | χ2/Fisher | P-Vale |
|---|---|---|---|---|---|
N | 237 | 136 | 3111 | ||
Aneuploidies | 9(3.80) | 23(16.91) | 240(7.71) | 20.99 | < 0.001 |
pathogenic CNVs | 5(2.11) | 5(3.68) | 83(2.67) | 0.93 | 0.60 |
22q11.2 | 5(2.11) | 1(0.74) | 11(0.35) | 16.961 | < 0.001 |
Others | 0(0.00) | 4(2.94) | 72(2.31) | ||
likely pathogenic CNVs | 0(0.0) | 0(0.0) | 10(0.32) | 0.037 | 1.00 |
pathogenic and likely pathogenic CNVs | 14(5.91) | 28(20.59) | 411(13.21) | 17.59 | < 0.001 |
variation unknown significance CNVs | 9(3.80) | 6(4.41) | 181(5.82) | 2.09 | 0.35 |
