Table 3 Univariate and multivariate analyses of predictors of DFS.

Age

1.941

0.612–6.155

0.260

Sex

1.016

0.990–1.034

0.236

Smoking status

1.052

0.457–2.421

0.905

Alcohol consumption

1.006

0.637–1.589

0.980

Tumor location

Glottic

Ref

Supraglottic

1.517

0.934–2.463

0.092

Subglottic

0.938

0.285–3.083

0.916

CT-reported AC invasion

1.205

0.723–2.010

0.475

Histological grade

1.250

0.676–2.311

0.477

Clinical T stage

cT1

Ref

Ref

cT2

0.868

0.425–1.775

0.699

0.606

0.149–2.466

0.484

cT3

2.134

1.169–3.894

0.014*

1.015

0.221–4.664

0.985

cT4

0.750

0.312–1.806

0.522

0.324

0.059–1.780

0.195

Clinical N stage

2.138

1.384–3.303

0.001*

2.191

1.241–3.869

0.007*

Overall clinical stage

I

Ref

Ref

II

0.999

0.478–2.087

0.998

1.206

0.293–4.964

0.795

III

2.112

1.111–4.015

0.023*

1.284

0.263–6.272

0.757

IV

1.593

0.801–3.167

0.184

0.888

0.155–5.074

0.894

2D DL signature

3.961

1.769–8.867

0.001*

4.666

1.861–11.698

0.001*