Fig. 1 | Scientific Reports

Fig. 1

From: Selective HDAC6 inhibitor WT161 modulates the VLA-4/FAK pathway by inhibiting PKA activity in acute lymphoblastic leukemia

Fig. 1The alt text for this image may have been generated using AI.

HDAC6 expression in ALL cell lines and the effect of WT161 on HDAC6, acetyl-α-tubulin, and cell proliferation. (a) HDAC6 protein expression in four ALL cell lines (BALL-1, NALM-6, Jurkat, and MOLT-4) as detected by Western blot. (b) Relative HDAC6 mRNA levels measured by quantitative PCR (qPCR), showing expression trends consistent with (a). (c) Western blot analysis of HDAC6 and acetyl-α-tubulin protein levels in cell lines treated with or without 5 µM WT161 for 72 h. (d) Concentration- and time-dependent inhibition of cell proliferation by WT161 across all four ALL cell lines. IC50 values were calculated to quantify compound sensitivity.

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